Grace Nakimera first appeared on the public scene in 2005 with a single titled Ani Akumanyi. This song featured Pentagon and Gatimo. Ani Akumanyi was one of the biggest hits in 2005. She then took a music break and only resurfaced after two years. This marked her return to active music. Between 2007 and now, Grace Nakimera has released several songs that went on to top music charts with in East Africa. These include Kiva Kuki, Kawonawo, Onyambanga, Sukuma, Anfukula, Nnavo Naawe, Osobola, Welaga Ki and Bagala Kiki featuring Aziz Azion. In 2010, Grace Nakimera held a gigantic show that was dubbed Grace Nakimera concert. This show is the biggest show ever in the history of Ugandan female singers’ concerts. Grace Nakimera has made a name with her continuous production of splendid videos.